Reproductive Immunology Laboratory Panels: When to Test

Recurrent Miscarriage

Test	12 weeks pre-procedure	Upon confirmation pregnancy (+HCG)	Every 4 weeks through 24	12 & 24 weeks gestation
APLA	X	X	X
APA	X	X		X
ANA	X	X		X
IP	X	X		X
NKA	X	X		*
DQA	X
DQB#	+
F II P	X
F V L	X
MTHFR	X

Infertility, pre-IVF/ET

Test	4 weeks before procedure	4 weeks gestation	12 weeks gestation
APA	X	X	X
ATA	X
IP	X	X	X
NKA	X	X	*
DQA	X
DQB#	+

# Investigational
* Repeat if IP is abnormal
+ Perform on male if couple shares DQA 4 or if male is DQA 2, 2

ANA - Antinuclear Antibodies
APA - Antiphospholipid Antibodies
APLA - Antipaternal Leukocyte Antibodies
ATA - Antithyroid Antibodies
DQA - DQ Alpha
DQB - DQ Beta
IP - Immunophenotype
NKA - Natural Killer Cell Assay
F II P - Factor II (prothrombin) Mutation
F V L - Factor V Leiden Mutation
MTHFR - Methylene Tetrahydrofolate Reductase Mutation