IVF Protocols

Pre-IVF Laboratory Tests

• Antiphospholipid antibody panel (APA)
• Antithyroid antibody panel (ATA)
• Immunophenotype (IP)
• Natural Killer cells with IVIg (NK+IVIg)
• (DQA1 on partners is recommended)
  
  (For more information see laboratory studies)

Treatment

• APA+
  
  • Heparin 5000 u sq BID 2 weeks prior to transfer.
  • Aspirin 81 mg QD 2 weeks prior to transfer.
    
    If patient has PE or PS IgG or IgM, IVIg 500 mg/kg X 1 dose, 5 to 7 days prior to transfer.
    
    
  • IVIg is also indicated for patients who have had 4+ failed IVFs and APA+.
• ATA+
  
  • Heparin 5000 u sq BID 2 weeks prior to transfer.
  • Aspirin 81 mg QD 2 weeks prior to transfer.
  • IVIg 500 mg/kg X 1 dose, 5 to 7 days prior to transfer.
  
  
• IP - Abnormal CD 56+/CD 16+ or CD 5+/CD 19+
  
  • IVIg 400 mg/kg X 3 consecutive days.
  • Repeat IP q month and treat with IVIg until IP normalizes.
    
    
• NK+IVIg - same as for abnormal IP.