Reproductive Immunology Associates Reproductive Immunology Associates
Reproductive Immunology Associates
(805) 578-7000
(805) 578-7004

Miscarriage Protocols

Pre-Pregnancy Laboratory Tests

  • Antinuclear antibody panel (ANA)
  • Antiphospholipid antibody panel (APA)
  • Leukocyte antibody detection
  • Immunophenotype
  • (DQA1 on partners, and NK cell with IVIg on female recommended)

    (For more information see laboratory studies)


  • ANA+
    • Prednisone 5 mg BID 5 days prior to conception.
    • Prednisone 10 mg BID on confirmation of pregnancy. Continue through week 20-24 gestation, then taper over 4 weeks.

      (If patient has not gotten pregnant within 3 months of starting prednisone, recommend 1 month hiatus.)
  • APA +
    • Heparin 5000 u sq BID 5 days prior to conception.
    • Aspirin 81 mg QD 5 days prior to conception.

      (Both meds are continued through week 34 gestation.)
  • Leukocyte Antibody Detection - low
    • IVIG 200mg/Kg per day for one day, 7-10 days prior to ovation. Repeat every month as long as blocking antibodies are low.
  • Immunophenotype - Abnormal CD 56+/CD 16+ or CD 5+/CD 19+
    • IVIg q month until immunophenotype normalizes.
    • Order NK with IVIg to determine dose of IVIg.
    • If borderline, can repeat IP or test partners DQA1.
- Laboratory tests are repeated every trimester.
- Dr. Matzner is always available by phone or e-mail to assist you.